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Availability. Size / Price. Qty. KT5720 is a hexylester derivative of K-252a and is a selective inhibitor of PKA (Ki =0.056 µM). Cell permeable. Product Specification We show that KT5720 and U-98017 effectively inhibit mitogen-activated protein kinase (MAPK) activity in vitro.

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Size / Price. Qty. KT5720 is a hexylester derivative of K-252a and is a selective inhibitor of PKA (Ki =0.056 µM).

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Scientific background KT5720 is a semi-synthetic derivative of K525a. It is a cell-permeable, selective inhibitor of cAMP-dependent protein kinase (PKA; IC 50 = 56 nM). No significant effect on protein kinase C (PKC), protein kinase G (PKG) or myosin light chain kinase (MLCK), was observed. 1 KT5720 was used to examine the role of PKA in various cellular events such as cell adhesion, 2 neurite Selected citations for KT 5720 include: Salinar et al (2020) Imiquimod suppresses respiratory syncytial virus (RSV) replication via PKA pathway and reduces RSV induced-inflammation and viral load in mice lungs Antiviral Res 179 PMID: 32387475 KT5720, protein kinase A inhibitor (ab141818) KT 5720 is one of a family of compounds synthesized by the fungus Nocardiopsis sp.

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